Bilateral femoral head necrosis and pathological fractures resulted from Fanconi syndrome due to adefovir dipivoxil treatment: a case report and systematic analysis of 7 cases

We presented a case of a patient underwent bilateral total hip arthroplasty for femoral head necrosis and pathological femoral neck fracture resulted from adefovir dipivoxil related Fanconi syndrome. Then, we ran a systematic analysis of seven similar cases. Surgical treatment was used in three cases, while no surgical treatment was conducted in the other four. Satisfactory clinic outcome was achieved in all 7 cases. As conclusion, hypophosphatemic osteomalacia is a potential risk for any patients who undergo adefovir dipivoxil treatment. And early intervention could improve the symptoms and prevent pathological fractures or bone necrosis.